Maintaining a vibrant and weed-free centipede grass lawn requires an effective weed killer tailored to this unique grass type. Centipede grass is sensitive to many common herbicides, so choosing the right product is crucial to eliminate broadleaf weeds and grassy invaders without damaging your lawn. Below is a summary table highlighting some of the top weed killers designed specifically for centipede grass, followed by detailed reviews of the best picks available on Amazon.
| Product Name | Brand | Key Feature | Size |
|---|---|---|---|
| Southern Ag 006130 Atrazine St. Augustine Weed Killer 32oz | Southern Ag | Controls weeds in centipede and St. Augustine grasses | 32 oz |
| Southern Ag Atrazine St. Augustine Grass Weed Killer, 1 Gallon | Southern Ag | Kills broadleaf weeds and suppresses crabgrass | 1 Gallon |
| Hi-Yield Atrazine Weed Killer | VPG | Prevents annual bluegrass and chickweed in centipede lawns | 32 oz |
| Spectracide Weed Stop For Lawns Concentrate, 32-Ounce, 6-Pack | Spectracide | Contains atrazine, controls weeds without harming lawn | 32 oz (6-pack) |
| Roundup Weed and Grass Killer₄ with Pump ‘N Go 2 Sprayer | Roundup | Kills tough weeds and grasses including dandelion and crabgrass | 1.33 Gallons |
Southern Ag 006130 Atrazine St. Augustine Weed Killer 32oz

The Southern Ag 006130 Atrazine St. Augustine Weed Killer is a specialized herbicide formulated for use on centipede and St. Augustine grasses. Each quart treats up to 3,720 square feet, offering extensive coverage for medium-sized lawns. This product efficiently targets a variety of broadleaf weeds commonly found in southern lawns without harming the centipede grass itself. It’s designed to preserve your lawn’s health while wiping out invasive weeds.
- One quart treats 3,720 sq ft
- Safe for centipede and St. Augustine grasses
- Light tan, easy-to-apply liquid formulation
- Package weight: 1.021 kilograms
Southern Ag Atrazine St. Augustine Grass Weed Killer, 1 Gallon

This one-gallon concentrate from Southern Ag offers a powerful solution for killing many broadleaf weeds while also effectively suppressing crabgrass in centipede grass lawns. Its formula is carefully developed to be safe on fragile centipede and St. Augustine grasses, making it a versatile weed control option for southern homeowners. The product helps maintain a healthy, weed-free turf with consistent use.
- Effective on a wide range of broadleaf weeds
- Also suppresses crabgrass growth
- Safe for centipede grass use
- Ideal for larger lawn areas
Hi-Yield Atrazine Weed Killer For Centipede Grass

Hi-Yield’s Atrazine Weed Killer is formulated with 4% Atrazine, making it efficient at controlling annual bluegrass, chickweed, and other common weeds in centipede and St. Augustine grass lawns. Its selective action ensures that it targets weeds while sparing the desirable grass. The product is a popular choice for maintaining healthy southern turfgrass with broad weed coverage.
- Contains 4.00% Atrazine active ingredient
- Controls annual bluegrass, chickweed, mouseear, and more
- Designed for use in St. Augustine and centipede grass
- Liquid concentrate for thorough application
Spectracide Weed Stop For Lawns For Centipede Lawns Concentrate

The Spectracide Weed Stop Concentrate contains Atrazine and is formulated specifically to control weeds on all St. Augustine and centipedegrass varieties. This ready-to-spray product kills both emerged weeds and prevents weeds from seed germination without damaging your lawn when used as directed. Its formulation offers a safe and effective approach to lawn maintenance.
- Kills weeds without harming lawns
- Controls both emerged and seedling weeds
- Contains Atrazine for selective weed control in southern grasses
- 32-ounce ready-to-spray concentrate; 6-pack available
Roundup Weed and Grass Killer₄ With Pump ‘N Go Sprayer

Unlike selective weed killers, Roundup Weed and Grass Killer₄ is a non-selective herbicide that kills weeds and grasses to the root. It’s effective against tough weeds like dandelion, crabgrass, poison ivy, and clover. This product is suitable for use around flower beds, trees, and other non-lawn areas where you want to remove all vegetation. It becomes rainproof within 30 minutes and provides visible results quickly.
- Kills tough weeds and grasses including crabgrass and dandelion
- Rainproof in 30 minutes for quick effectiveness
- Includes a Pump ‘N Go 2 sprayer for easy application
- Allows planting 1 to 30 days post-application based on plant type
Buying Guide: Choosing The Best Weed Killer For Centipede Grass
Selectivity and Safety: Centipede grass is sensitive to many herbicides, so prioritize products labeled safe for centipede grass to avoid lawn damage. Selective herbicides containing atrazine or similar active ingredients are preferred for targeting broadleaf weeds without harming grass.
Weed Type: Identify the predominant weed species affecting your lawn. Some products excel in controlling broadleaf weeds such as dandelions and chickweed, while others also suppress grassy weeds like crabgrass. This helps in selecting the most effective herbicide.
Application Area Size: Consider the size of your lawn to determine whether a quart, gallon, or concentrate pack suits your needs best. Larger lawns benefit from gallon-sized or multi-pack concentrates to cover extensive areas economically.
Ease of Use: Ready-to-spray concentrates or those with included sprayers provide convenience, especially if you lack professional spraying equipment. Liquid concentrates require mixing but allow customization of application rates.
Speed of Results: Some formulas, like non-selective herbicides, offer visible weed death within hours, while selective ones may take longer. Evaluate how quickly you want to see effects and whether you need safe application around your lawn or garden plants.
Additional Benefits: Certain products combine weed control with lawn feeding, delivering nutrients alongside herbicide action. These can improve lawn health while managing weeds simultaneously but consider whether your lawn needs fertilization.